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You should stop your activity if you think you are getting frostbite, if you are losing sensation in your fingers, hands, toes, or feet or if you feel tingling (“pins and needles sensation”) or pain. Often, as the skin of fingers and toes cools below its normal temperatures, it goes through two phases: (1) Pain and tingling, then (2) loss of sensation. While they may feel better when numb, it is a serious warning sign that frostbite is possible if you do not immediately warm them back up.
You should rewarm frostbite in hot water. The water should be hot but tolerable to the touch. Do not use boiling water. Use a bath or basin to immerse your frozen hands or feet and let them thaw for approximately 30 minutes, or until the fingers and toes are soft and can bend easily.
Thawing frostbite can be painful. Use medications such as ibuprofen (Advil) or ASA (Aspirin) to treat the pain if you are not at risk of bleeding.
If you have rewarmed your skin and it looks or feels abnormal for more than an hour later, you should seek medical attention to be safe.
You should rewarm or thaw frostbitten hands or feet only if you can keep them warm afterward. Re-freezing your frostbitten hands or feet after thawing can be very damaging.
If you are in a remote environment and you cannot immerse your frostbitten hands or feet in hot water, protect them from further cold exposure and seek medical attention immediately.
Frostbite generally does not get infected. Infection can happen if severe frostbite causes severe blisters, bleeding, a break in the skin, and if the wounds are not properly cleaned and cared for.
Skin infection can appear red, inflamed, swollen, and can cause pus or liquid to drain. Seek medical attention if you suspect skin infection.
Avoid wearing jewelry such as rings, bracelets, or watches or tight footwear on frostbitten parts. Take a hot bath daily to cleanse wounds and promote blood circulation and healing. Taking a bath with jets can act as a gentle wound cleanser and can further promote circulation. Keep your wounds clean and use aloe vera gel if possible. Protect your frostbite wounds from any trauma such as banging, rubbing, dragging, etc. Use bulky, non-adhesive bandages to create protection against banging or rubbing. Avoid using tight bandages or bandages that stick on the wounds. If possible, elevate your hands or feet. Avoid walking on frostbitten feet. Seek medical attention if you notice any worsening.
There are promising treatments used in different parts of the world for frostbite. Treatments are used to prevent damage to the skin and tissue after rewarming. If not treated, severe frostbite can block the blood circulation in the extremities and cause the tissue to turn black (“necrosis”). Frostbite treatments are used to prevent amputation.
The first step is to thaw the frostbite by immersing the frozen body parts in hot water for 30 minutes. Water should be hot but tolerable to the touch. Some hospitals use a rewarming basin with moving water, such as a whirlpool, and add an antiseptic/gentle cleansing soap. The frostbitten body parts should be cleaned gently, with dirt or debris removed. Remove jewelry, rings, bracelets, or watches. Let the body parts air dry and protect from injury.
Ibuprofen or ASA can be used to treat the pain if you do not have a risk of bleeding, allergies or contraindications. Ibuprofen and ASA can also treat frostbite by preventing blood clots and improving blood circulation. Ibuprofen and ASA have been studied in animals and patients with frostbite and can help prevent amputation.
The gel from the plant aloe vera has been studied in animals and patients with frostbite. It can help with healing, improving circulation, preventing infection, and preventing amputation. Use a product that does not contain alcohol or topical anesthetics, and is not sticky.
If you have not received a tetanus-diphtheria vaccine in the last 10 years, you may receive a shot to prevent infection.
Iloprost is an injectable medication that is available in some hospitals to treat frostbite. It can help restore blood flow in the extremities and prevent blood clot. It can help prevent amputation. To find out where iloprost is available, visit the Contact page or contact your local hospital.
Iloprost was approved by the FDA in the US for use in frostbite in February 2024 (1).
Thrombolytics (also called "clot busters"), such as alteplase, are used to treat frostbite. It is a medication given by injection that stops blood clots. While more commonly used for heart attacks and strokes, it can be used after frostbite to prevent death of tissue and amputation. It has been studied in small groups of patients with frostbite and appears to reduce the risk of amputation. Alteplase can cause rare but serious bleeding.
Anticoagulants such as enoxaparin can be used with other frostbite treatments to prevent more blood clots. They are generally not used alone to treat frostbite.
A doctor or nurse can clean the blisters when they appear (generally 1 day after rewarming). Some doctors may use a syringe and a needle to aspirate the liquid from the blisters, if the blisters are clear. Bloody blisters should not be drained unless over a joint, or breaking down already.
Some studies suggest that breathing pure oxygen in a pressurized tank can help bring more oxygen to the frostbitten parts. It may reduce the risk for amputation.
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Lorentzen AK, Penninga L. Frostbite-A Case Series From Arctic Greenland. Wilderness Environ Med. 2018 Sep;29(3):392–400.
Zhang Y, Song J, Huang G. Comprehensive Treatment of Single Finger Frostbite: A Case Study. J Burn Care Res Off Publ Am Burn Assoc. 2021 May 7;42(3):555–9.
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Davis A, Sinopoli B, Mann N, Stenbit AE. A Photographic Case of Frostbite Treated with Delayed Hyperbaric Oxygen Therapy. High Alt Med Biol. 2022 Jun;23(2):194–7.
Coward A, Endorf FW, Nygaard RM. Revision Surgery Following Severe Frostbite Injury Compared to Similar Hand and Foot Burns. J Burn Care Res Off Publ Am Burn Assoc. 2022 Sep 1;43(5):1015–8.
Endorf FW, Nygaard RM. Social Determinants of Poor Outcomes Following Frostbite Injury: A Study of the National Inpatient Sample. J Burn Care Res Off Publ Am Burn Assoc. 2021 Nov 24;42(6):1261–5.
Rossis CG, Yiacoumettis AM, Elemenoglou J. Squamous cell carcinoma of the heel developing at site of previous frostbite. J R Soc Med. 1982 Sep;75(9):715–8.
Mohr WJ, Jenabzadeh K, Ahrenholz DH. Cold injury. Hand Clin. 2009 Nov;25(4):481–96.
Weatherley-White RCA, Sjostrom B, Paton BC. Experimental studies in cold injury: II. The pathogenesis of frostbite. J Surg Res. 1964 Jan 1;4(1):17–22.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
Zhang Y, Song J, Huang G. Comprehensive Treatment of Single Finger Frostbite: A Case Study. J Burn Care Res Off Publ Am Burn Assoc. 2021 May 7;42(3):555–9.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
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McIntosh SE, Freer L, Grissom CK, Rodway GW, Giesbrecht GG, McDevitt M, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2024 Update. Wilderness Environ Med. 2024 Jun;35(2):183–97.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
Manson PN, Jesudass R, Marzella L, Bulkley GB, Im MJ, Narayan KK. Evidence for an early free radical-mediated reperfusion injury in frostbite. Free Radic Biol Med. 1991;10(1):7–11.
McCauley RL, Heggers JP, Robson MC. Frostbite. Methods to minimize tissue loss. Postgrad Med. 1990 Dec;88(8):67–8, 73–7.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983 Feb;23(2):143–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983 Feb;23(2):143–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
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Ilomedin Package Insert. Bayer HealthCare
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