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This is a non-exhaustive list of healthcare facilities and professionals with experience in providing frostbite care around the world, including healthcare facilities with established frostbite care pathways and protocols. The aim of this list is to facilitate frostbite care access and collaboration in providing frostbite care.
Healthcare professionals may use this “Transfer of Care Form” to provide information to the next provider of care when transferring a patient from one healthcare facility to another (e.g. patient details, frostbite injury/event description and treatment provided).
For any other inquiries, visit the Canadian Frostbite Care Network Contact page.
The Canadian Frostbite Care Network does not provide formal medical consultations or specific medical advice. Frostbite assessment and care is variable between centres and physicians, as currently there is no clearly defined standard of care in the medical literature.
Patients are encouraged to connect with their local care teams through the Emergency Department and/or Primary Care provider, who are best positioned to facilitate consultation and/or transfer of care to appropriate local specialists or one of the centres listed below.
28 Oki Drive, Calgary, Alberta, T3B 6A8, Canada
Direct point of contact:
Dr. Simon J Parson
Dr. Frankie Fraulin
Services offered:
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1403 29st NW, Calgary, Alberta, Canada
Direct point of contact:
Burns surgeon
For care providers:
Referral, Access, Advice, Placement, Information & Destination (RAAPID)
RAAPID South for patients in and south of Red Deer, Alberta
1-800-661-1700 (Canada ONLY)
403-944-4486
Services offered:
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Direct point of contact:
For care providers:
Referral, Access, Advice, Placement, Information & Destination (RAAPID)
RAAPID North (for patients north of Red Deer, Alberta)
1-800-282-9911 (Canada ONLY)
780-735-0811
Services offered:
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8440 112st NW, Edmonton, Alberta, Canada
Direct point of contact:
Burns surgeon
For care providers:
Referral, Access, Advice, Placement, Information & Destination (RAAPID)
RAAPID North (for patients north of Red Deer, Alberta)
1-800-282-9911 (Canada ONLY)
780-735-0811
Services offered:
Cariboo Memorial Hospital, 100 mile District Hospital, Royal Inland Hospital, Shuswap Lake General Hospital, Kelowna General Hospital, Kootenay Lake Hospital, East Kootenay Regional Hospital and Golden and District Hospital, British Columbia, Canada
Direct point of contact:
Services offered:
1796 Summer Street, Halifax, Nova Scotia, B3H 3A6
Direct point of contact:
Dr. Jack Rasmussen
Pharmacy Department
Jessica Sellers
Services offered:
764 rue Sivuarapik, Puvirnituq, Québec, J0M 1P0, Canada
Direct point of contact:
Médecin de l'unité de soins
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290 rue de Montigny, Saint Jérôme, Québec, J7Z 5T3, Canada
Direct point of contact:
Dr. Éric Contan, MD, M.Sc, CCFP-EM
Services offered:
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Kuujjuaq, Québec, Canada
Direct point of contact:
Services offered:
Yukon Surgical Clinic, Whitehorse General Hospital, Whitehorse, Yukon, Y1A 3H7, Canada
Direct point of contact:
Dr. Alex Poole
Pharmacy department
Josianne Gauthier
Services offered:
Turuntie 150, 02740 Espoo, Finland
Direct point of contact:
Dr. Andrew Lindford
Services offered:
Hopitaux des Pays du Mont Blanc, 559 route des pélerins, 74400 Chamonix , FRANCE
Pierre Doctors: Pascal Zellener, Pierre Muller, Francois Lecoq, Guy Duperrex
Services offered:
Lainchaur, Kathmandu, Nepal
Direct point of contact:
Dr. Suvash Dawadi
Services offered:
14 Queens Street, Timaru. 7910. New Zealand
Direct point of contact:
Dr. Robin Barraclough
Services offered:
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DR. RICHARD D PRICE
248 Hadlow Road RD4 Timaru. 7974. New Zealand
Direct point of contact:
Dick Price
Services offered:
ability to conduct remote, virtual assessments
clinic follow up
UHCW NHS Trust, Clifford Bridge Rd, Coventry CV4 7HH
Direct point of contact:
Prof Imray, Specialist Surgical Services, 3rd Floor
Services offered:
JBER Hospital, Anchorage Alaska 99505, USA
Direct point of contact:
Titus Rund DO, MPH
Services offered:
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2801 DeBarr Rd Anchorage, AK 99508
Direct point of contact:
Dr. Jennifer Dow, MD
Services offered:
---
701 Park Ave, Minneapolis, MN 55415, United States
Contact:
1-800-424-4262 or 612-873-3000
Services offered:
---
640 Jackson St, St Paul, Minneapolis, MN 55101, United States
Contact:
1-800-922-2876 (BURN)
Services offered:
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Commissioner O of the. FDA. FDA; 2024 [cited 2024 Jun 27]. FDA Approves First Medication to Treat Severe Frostbite. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite.
Lorentzen AK, Penninga L. Frostbite-A Case Series From Arctic Greenland. Wilderness Environ Med. 2018 Sep;29(3):392–400.
Commissioner O of the. FDA. FDA; 2024 [cited 2024 Jun 27]. FDA Approves First Medication to Treat Severe Frostbite. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite.
Lorentzen AK, Penninga L. Frostbite-A Case Series From Arctic Greenland. Wilderness Environ Med. 2018 Sep;29(3):392–400.
Zhang Y, Song J, Huang G. Comprehensive Treatment of Single Finger Frostbite: A Case Study. J Burn Care Res Off Publ Am Burn Assoc. 2021 May 7;42(3):555–9.
McIntosh SE, Freer L, Grissom CK, Auerbach PS, Rodway GW, Cochran A, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update. Wilderness Environ Med. 2019 Dec 1;30(4):S19–32.
Lorentzen AK, Penninga L. Frostbite-A Case Series From Arctic Greenland. Wilderness Environ Med. 2018 Sep;29(3):392–400.
Zhang Y, Song J, Huang G. Comprehensive Treatment of Single Finger Frostbite: A Case Study. J Burn Care Res Off Publ Am Burn Assoc. 2021 May 7;42(3):555–9.
McIntosh SE, Freer L, Grissom CK, Auerbach PS, Rodway GW, Cochran A, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update. Wilderness Environ Med. 2019 Dec 1;30(4):S19–32.
Regli IB, Strapazzon G, Falla M, Oberhammer R, Brugger H. Long-Term Sequelae of Frostbite-A Scoping Review. Int J Environ Res Public Health. 2021 Sep 14;18(18):9655.
Higdon B, Youngman L, Regehr M, Chiou A. Deep Frostbite Treated With Hyperbaric Oxygen and Thrombolytic Therapies. Wounds Compend Clin Res Pract. 2015 Aug;27(8):215–23.
Davis A, Sinopoli B, Mann N, Stenbit AE. A Photographic Case of Frostbite Treated with Delayed Hyperbaric Oxygen Therapy. High Alt Med Biol. 2022 Jun;23(2):194–7.
Coward A, Endorf FW, Nygaard RM. Revision Surgery Following Severe Frostbite Injury Compared to Similar Hand and Foot Burns. J Burn Care Res Off Publ Am Burn Assoc. 2022 Sep 1;43(5):1015–8.
Endorf FW, Nygaard RM. Social Determinants of Poor Outcomes Following Frostbite Injury: A Study of the National Inpatient Sample. J Burn Care Res Off Publ Am Burn Assoc. 2021 Nov 24;42(6):1261–5.
Rossis CG, Yiacoumettis AM, Elemenoglou J. Squamous cell carcinoma of the heel developing at site of previous frostbite. J R Soc Med. 1982 Sep;75(9):715–8.
Mohr WJ, Jenabzadeh K, Ahrenholz DH. Cold injury. Hand Clin. 2009 Nov;25(4):481–96.
Weatherley-White RCA, Sjostrom B, Paton BC. Experimental studies in cold injury: II. The pathogenesis of frostbite. J Surg Res. 1964 Jan 1;4(1):17–22.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
Manson PN, Jesudass R, Marzella L, Bulkley GB, Im MJ, Narayan KK. Evidence for an early free radical-mediated reperfusion injury in frostbite. Free Radic Biol Med. 1991;10(1):7–11.
Robson MC, Heggers JP. Evaluation of hand frostbite blister fluid as a clue to pathogenesis. J Hand Surg. 1981 Jan;6(1):43–7.
McIntosh SE, Freer L, Grissom CK, Rodway GW, Giesbrecht GG, McDevitt M, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2024 Update. Wilderness Environ Med. 2024 Jun;35(2):183–97.
Wibbenmeyer L, Lacey AM, Endorf FW, Logsetty S, Wagner ALL, Gibson ALF, et al. American Burn Association Clinical Practice Guidelines on the Treatment of Severe Frostbite. J Burn Care Res Off Publ Am Burn Assoc. 2023 Apr 13;irad022.
Higdon B, Youngman L, Regehr M, Chiou A. Deep Frostbite Treated With Hyperbaric Oxygen and Thrombolytic Therapies. Wounds Compend Clin Res Pract. 2015 Aug;27(8):215–23.
Davis A, Sinopoli B, Mann N, Stenbit AE. A Photographic Case of Frostbite Treated with Delayed Hyperbaric Oxygen Therapy. High Alt Med Biol. 2022 Jun;23(2):194–7.
Coward A, Endorf FW, Nygaard RM. Revision Surgery Following Severe Frostbite Injury Compared to Similar Hand and Foot Burns. J Burn Care Res Off Publ Am Burn Assoc. 2022 Sep 1;43(5):1015–8.
Endorf FW, Nygaard RM. Social Determinants of Poor Outcomes Following Frostbite Injury: A Study of the National Inpatient Sample. J Burn Care Res Off Publ Am Burn Assoc. 2021 Nov 24;42(6):1261–5.
Rossis CG, Yiacoumettis AM, Elemenoglou J. Squamous cell carcinoma of the heel developing at site of previous frostbite. J R Soc Med. 1982 Sep;75(9):715–8.
Mohr WJ, Jenabzadeh K, Ahrenholz DH. Cold injury. Hand Clin. 2009 Nov;25(4):481–96.
Weatherley-White RCA, Sjostrom B, Paton BC. Experimental studies in cold injury: II. The pathogenesis of frostbite. J Surg Res. 1964 Jan 1;4(1):17–22.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
Zhang Y, Song J, Huang G. Comprehensive Treatment of Single Finger Frostbite: A Case Study. J Burn Care Res Off Publ Am Burn Assoc. 2021 May 7;42(3):555–9.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
Gauthier J, Morris-Janzen D, Poole A. Iloprost for the treatment of frostbite: a scoping review. Int J Circumpolar Health. 2023 Dec;82(1):2189552.
Quintanilla R, Krusen FH, Essex HE. Studies on frost-bite with special reference to treatment and the effect on minute blood vessels. Am J Physiol. 1947 Apr;149(1):149–61.
McCauley RL, Heggers JP, Robson MC. Frostbite. Methods to minimize tissue loss. Postgrad Med. 1990 Dec;88(8):67–8, 73–7.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983 Feb;23(2):143–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
McIntosh SE, Freer L, Grissom CK, Rodway GW, Giesbrecht GG, McDevitt M, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2024 Update. Wilderness Environ Med. 2024 Jun;35(2):183–97.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
Manson PN, Jesudass R, Marzella L, Bulkley GB, Im MJ, Narayan KK. Evidence for an early free radical-mediated reperfusion injury in frostbite. Free Radic Biol Med. 1991;10(1):7–11.
McCauley RL, Heggers JP, Robson MC. Frostbite. Methods to minimize tissue loss. Postgrad Med. 1990 Dec;88(8):67–8, 73–7.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983 Feb;23(2):143–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983 Feb;23(2):143–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
Kahle AC, Cooper JS. Hyperbaric Physiological And Pharmacological Effects of Gases. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Dec 29]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK470481/
Gawdi R, Cooper JS. Hyperbaric Contraindications. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Jun 27]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK557661/
Ghumman A, St Denis-Katz H, Ashton R, Wherrett C, Malic C. Treatment of Frostbite With Hyperbaric Oxygen Therapy: A Single Center’s Experience of 22 Cases. Wounds Compend Clin Res Pract. 2019 Dec;31(12):322–5.
Magnan MA, Gayet-Ageron A, Louge P, Champly F, Joffre T, Lovis C, et al. Hyperbaric Oxygen Therapy with Iloprost Improves Digit Salvage in Severe Frostbite Compared to Iloprost Alone. Med Kaunas Lith. 2021 Nov 22;57(11):1284.
Frostbite: Spectrum of Imaging Findings and Guidelines for Management | RadioGraphics [Internet]. [cited 2020 Oct 19]. Available from: https://pubs.rsna.org/doi/10.1148/rg.2016160045
Bruen KJ, Ballard JR, Morris SE, Cochran A, Edelman LS, Saffle JR. Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy. Arch Surg Chic Ill 1960. 2007 Jun;142(6):546–51; discussion 551-553.
Ibrahim AE, Goverman J, Sarhane KA, Donofrio J, Walker TG, Fagan SP. The emerging role of tissue plasminogen activator in the management of severe frostbite. J Burn Care Res Off Publ Am Burn Assoc. 2015;36(2):e62-66.
Frostbite: Spectrum of Imaging Findings and Guidelines for Management | RadioGraphics [Internet]. [cited 2020 Oct 19]. Available from: https://pubs.rsna.org/doi/10.1148/rg.2016160045
Santapau A, Razola P, Tardin L, Andrés A, Prats E, Banzo J. The role of bone scanning in severe frostbite of the feet in a mountaineer. Rev Espanola Med Nucl E Imagen Mol. 2013 Mar;32(2):113–4.
Cauchy E, Chetaille E, Lefevre M, Kerelou E, Marsigny B. The role of bone scanning in severe frostbite of the extremities: a retrospective study of 88 cases. Eur J Nucl Med. 2000 May;27(5):497–502.
Frostbite: Spectrum of Imaging Findings and Guidelines for Management | RadioGraphics [Internet]. [cited 2020 Oct 19]. Available from: https://pubs.rsna.org/doi/10.1148/rg.2016160045
Lacey AM, Fey RM, Gayken JR, Endorf FW, Schmitz KR, Punjabi GV, et al. Microangiography: An Alternative Tool for Assessing Severe Frostbite Injury. J Burn Care Res Off Publ Am Burn Assoc. 2019 Aug 14;40(5):566–9.
Raleigh SM, Samson M, Nygaard R, Endorf F, Walter J, Masters T. Bedside Fluorescence Microangiography for Frostbite Diagnosis in the Emergency Department. West J Emerg Med. 2022 Oct 23;23(6):872–7.
Poole A, Gauthier J, MacLennan M. Management of severe frostbite with iloprost, alteplase and heparin: a Yukon case series. CMAJ Open. 2021 Jun;9(2):E585–91.
Early Mobilization in Lower Extremity Frostbite Injury: Preliminary Experience at a Single Burn Center - PubMed [Internet]. [cited 2024 Jun 27]. Available from: https://pubmed-ncbi-nlm-nih-gov.proxy.lib.nosm.ca/28570307/
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Frostbite: Spectrum of Imaging Findings and Guidelines for Management | RadioGraphics [Internet]. [cited 2020 Oct 19]. Available from: https://pubs.rsna.org/doi/10.1148/rg.2016160045
Cauchy E, Chetaille E, Lefevre M, Kerelou E, Marsigny B. The role of bone scanning in severe frostbite of the extremities: a retrospective study of 88 cases. Eur J Nucl Med. 2000 May;27(5):497–502.
Greenwald D, Cooper B, Gottlieb L. An algorithm for early aggressive treatment of frostbite with limb salvage directed by triple-phase scanning. Plast Reconstr Surg. 1998 Sep;102(4):1069–74.
Destruction of Phalangeal Epiphyses by Frostbite | Radiology [Internet]. [cited 2024 Jun 27]. Available from: https://pubs-rsna-org.proxy.lib.nosm.ca/doi/10.1148/93.4.859?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Vinson HA, Schatzki R. Roentgenologic Bone Changes Encountered in Frostbite, Korea 1950–51. Radiology. 1954 Nov;63(5):685–95.
Ellis R, Short JG, Simonds BD. Unilateral Osteoarthritis of the Distal Interphalangeal Joints Following Frostbite. Radiology. 1969 Oct;93(4):857–8.
Norheim A, Rannestad B, Howes R, Rein E, Jorum E, Friedl K, et al. Abstracts from The Cold Weather Operations Conference 2021. Int J CIRCUMPOLAR Health. 2022 Dec 31;81(1).
Fabian JC, Taljaard M, Perry JJ. A retrospective cohort study examining treatments and operative interventions for frostbite in a tertiary care hospital. CJEM. 2017 Mar;19(2):88–95.
Richard L, Golding H, Saskin R, Jenkinson JIR, Francombe Pridham K, Gogosis E, et al. Cold-related injuries among patients experiencing homelessness in Toronto: a descriptive analysis of emergency department visits. CJEM. 2023 Aug;25(8):695–703.
Endorf FW, Nygaard RM. Social Determinants of Poor Outcomes Following Frostbite Injury: A Study of the National Inpatient Sample. J Burn Care Res Off Publ Am Burn Assoc. 2021 Nov 24;42(6):1261–5.
Endorf FW, Alapati D, Xiong Y, DiGiandomenico C, Rasimas CS, Rasimas JJ, et al. Biopsychosocial factors associated with complications in patients with frostbite. Medicine (Baltimore). 2022 Aug 26;101(34):e30211.
Richard L, Golding H, Saskin R, Jenkinson JIR, Francombe Pridham K, Gogosis E, et al. Cold-related injuries among patients experiencing homelessness in Toronto: a descriptive analysis of emergency department visits. CJEM. 2023 Aug;25(8):695–703.
McIntosh SE, Freer L, Grissom CK, Rodway GW, Giesbrecht GG, McDevitt M, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2024 Update. Wilderness Environ Med. 2024 Jun;35(2):183–97.
Poole A, Ahmed Y, Davidson M. The Occasional frostbite. Can J Rural Med Off J Soc Rural Physicians Can J Can Med Rurale J Off Soc Med Rurale Can. 2024 Jan 1;29(1):30–6.
Murphy J, Endorf FW, Winters MK, Rogers C, Walter E, Neumann N, et al. Bleeding Complications in Patients With Severe Frostbite Injury. J Burn Care Res Off Publ Am Burn Assoc. 2023 Jul 5;44(4):745–50.
C R, Am L, Fw E, G P, A W, J G, et al. The Effects of Rapid Rewarming on Tissue Salvage in Severe Frostbite Injury. J Burn Care Res Off Publ Am Burn Assoc [Internet]. 2022 Jul 1 [cited 2024 Oct 8];43(4). Available from: https://pubmed.ncbi.nlm.nih.gov/34791315/
Lacey AM, Rogers C, Endorf FW, Fey RM, Gayken JR, Schmitz KR, et al. An Institutional Protocol for the Treatment of Severe Frostbite Injury-A 6-Year Retrospective Analysis. J Burn Care Res Off Publ Am Burn Assoc. 2021 Aug 4;42(4):817–20.
Hutchison RL, Miller HM, Michalke SK. The Use of tPA in the Treatment of Frostbite: A Systematic Review. Hand N Y N. 2019 Jan;14(1):13–8.
Heard J, Shamrock A, Galet C, Pape KO, Laroia S, Wibbenmeyer L. Thrombolytic Use in Management of Frostbite Injuries: Eight Year Retrospective Review at a Single Institution. J Burn Care Res Off Publ Am Burn Assoc. 2020 May 2;41(3):722–6.
Drinane J, Kotamarti VS, O’Connor C, Nair L, Divanyan A, Roth MZ, et al. Thrombolytic Salvage of Threatened Frostbitten Extremities and Digits: A Systematic Review. J Burn Care Res Off Publ Am Burn Assoc. 2019 Aug 14;40(5):541–9.
Drinane J, Heiman AJ, Ricci JA, Patel A. Thrombolytic Salvage of the Frostbitten Upper Extremity: A Systematic Review. Hand N Y N. 2022 May;17(3):397–404.
Nygaard RM, Lacey AM, Lemere A, Dole M, Gayken JR, Lambert Wagner AL, et al. Time Matters in Severe Frostbite: Assessment of Limb/Digit Salvage on the Individual Patient Level. J Burn Care Res Off Publ Am Burn Assoc. 2017 Feb;38(1):53–9.
C R, Am L, Fw E, G P, A W, J G, et al. The Effects of Rapid Rewarming on Tissue Salvage in Severe Frostbite Injury. J Burn Care Res Off Publ Am Burn Assoc [Internet]. 2022 Jul 1 [cited 2024 Oct 8];43(4). Available from: https://pubmed.ncbi.nlm.nih.gov/34791315/
Lacey AM, Rogers C, Endorf FW, Fey RM, Gayken JR, Schmitz KR, et al. An Institutional Protocol for the Treatment of Severe Frostbite Injury-A 6-Year Retrospective Analysis. J Burn Care Res Off Publ Am Burn Assoc. 2021 Aug 4;42(4):817–20.
Hutchison RL, Miller HM, Michalke SK. The Use of tPA in the Treatment of Frostbite: A Systematic Review. Hand N Y N. 2019 Jan;14(1):13–8.
Heard J, Shamrock A, Galet C, Pape KO, Laroia S, Wibbenmeyer L. Thrombolytic Use in Management of Frostbite Injuries: Eight Year Retrospective Review at a Single Institution. J Burn Care Res Off Publ Am Burn Assoc. 2020 May 2;41(3):722–6.
Drinane J, Kotamarti VS, O’Connor C, Nair L, Divanyan A, Roth MZ, et al. Thrombolytic Salvage of Threatened Frostbitten Extremities and Digits: A Systematic Review. J Burn Care Res Off Publ Am Burn Assoc. 2019 Aug 14;40(5):541–9.
Drinane J, Heiman AJ, Ricci JA, Patel A. Thrombolytic Salvage of the Frostbitten Upper Extremity: A Systematic Review. Hand N Y N. 2022 May;17(3):397–404.
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Heggers JP, Phillips LG, McCauley RL, et al. Frostbite: experimental and clinical evaluations of treatment. J Wilderness Med. 1990:27–32.
McCauley RL, Heggers JP, Robson MC. Frostbite. Methods to minimize tissue loss. Postgrad Med. 1990 Dec;88(8):67–8, 73–7.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987 Sep;16(9):1056–62.
Heggers JP, Phillips LG, McCauley RL, et al. Frostbite: experimental and clinical evaluations of treatment. J Wilderness Med. 1990:27–32.
Skolnick AA. Early data suggest clot-dissolving drug may help save frostbitten limbs from amputation. JAMA. 1992;267(15):2008–2010.
Hutchison RL, Miller HM, Michalke SK. The Use of tPA in the Treatment of Frostbite: A Systematic Review. Hand N Y N. 2019 Jan;14(1):13–8.
Drinane J, Kotamarti VS, O’Connor C, Nair L, Divanyan A, Roth MZ, et al. Thrombolytic Salvage of Threatened Frostbitten Extremities and Digits: A Systematic Review. J Burn Care Res Off Publ Am Burn Assoc. 2019 Aug 14;40(5):541–9.
Ilomedin Package Insert. Bayer HealthCare
Cauchy E, Cheguillaume B, Chetaille E. A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite. N Engl J Med. 2011;364(2):189-90.
Poole A, Gauthier J, MacLennan M. Management of severe frostbite with iloprost, alteplase and heparin: a Yukon case series. CMAJ Open. 2021 Jun;9(2):E585–91.
Poole A, Gauthier J. Treatment of severe frostbite with iloprost in northern Canada. CMAJ Can Med Assoc J J Assoc Medicale Can. 2016 Dec 6;188(17–18):1255–8.
Crooks S, Shaw BH, Andruchow JE, Lee CH, Walker I. Effectiveness of intravenous prostaglandin to reduce digital amputations from frostbite: an observational study. CJEM. 2022;24(6):622-629.
Lindford A, Valtonen J, Hult M, Kavola H, Lappalainen K, Lassila R, Aho P, Vuola J. The evolution of the Helsinki frostbite management protocol. Burns. 2017;43(7):1455-1463.
Cauchy E, Chetaille E, Pham E, et al. Iloprost With and Without rt-PA: Treatment of 131 Cases of Severe Frostbite. 7th World Congress of Mountain and Wilderness Medicine. Telluride, Colorado. July 30 - August 4, 2016. (Abstract)
Cauchy E, Cheguillaume B, Chetaille E. A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite. N Engl J Med. 2011;364(2):189-90.
Cauchy E, Chetaille E, Pham E, et al. Iloprost With and Without rt-PA: Treatment of 131 Cases of Severe Frostbite. 7th World Congress of Mountain and Wilderness Medicine. Telluride, Colorado. July 30 - August 4, 2016. (Abstract)
Pandey P, Vadlamudi R, Pradhan R, Pandey KR, Kumar A, Hackett P. Case Report: Severe Frostbite in Extreme Altitude Climbers-The Kathmandu Iloprost Experience. Wilderness Environ Med. 2018;29(3):366-374
Magnan DM, Gelsomino M, Louge P, Pignel R. Successful Delayed Hyperbaric Oxygen Therapy and Iloprost Treatment on Severe Frostbite at High Altitude. High Alt Med Biol. 2022;23(3):294-297.
Imray C, Grieve A, Dhillon S; Caudwell Xtreme Everest Research Group. Cold damage to the extremities: frostbite and non-freezing cold injuries. Postgrad Med J. 2009 Sep;85(1007):481-8
Lansdorp CA, Roukema GR, Boonstra O, Dokter J, van der Vlies C. Delayed treatment of frostbite with hyperbaric oxygen: a report of two cases. Undersea Hyperb Med J Undersea Hyperb Med Soc Inc. 2017;44(4):365–9.